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Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 1-gen-2012 Nesi, Giulia; Danesi, Romano; Lapucci, Annalina; Ricciardi, S; Sestito, Simona; Rapposelli, Simona
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 1-gen-2013 Nesi, Giulia; Sestito, Simona; Mey, V.; Ricciardi, S.; Falasca, M.; Danesi, Romano; Lapucci, Annalina; Breschi, MARIA CRISTINA; Fogli, Stefano; Rapposelli, Simona
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DI PDK1. 1-gen-2015 Sestito, Simona; Daniele, Simona; Martini, Claudia; Rapposelli, Simona; Puricelli, G.
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 1-gen-2015 Daniele, Simona; Costa, Barbara; Zappelli, Elisa; DA POZZO, Eleonora; Sestito, Simona; Nesi, Giulia; Campiglia, Pietro; Marinelli, Luciana; Novellino, Ettore; Rapposelli, Simona; Martini, Claudia
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 1-gen-2015 Sestito, Simona; Nesi, Giulia; Daniele, Simona; Martelli, Alma; Digiacomo, Maria; Borghini, Alice; Pietra, Daniele; Calderone, Vincenzo; Lapucci, Annalina; Falasca, Marco; Parrella, Paola; Notarangelo, Angelantonio; Breschi, MARIA CRISTINA; Macchia, Marco; Martini, Claudia; Rapposelli, Simona
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 1-gen-2016 Sestito, S; Daniele, S; Martini, C; Rapposelli, S; Puricelli, G.
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 1-gen-2016 Nesi, Giulia; Shengnan, Wang; Sestito, Simona; Chiara, Barbieri; Ziwei, Chen; Xiaohong, Yang; Rongbiao, Pi; Rapposelli, Simona
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DUALI DI PDK1/AurA” 1-gen-2016 Sestito, Simona; Daniele, Simona; Martini, Claudia; Rapposelli, Simona; Guido, Puricelli
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 1-gen-2016 Sestito, Simona; Daniele, Simona; Nesi, Giulia; Zappelli, Elisa; Di Maio, D; Marinelli, L; Digiacomo, Maria; Lapucci, Annalina; Martini, Claudia; Novellino, E; Rapposelli, Simona
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study. 1-gen-2016 Chiellini, Grazia; Nesi, Giulia; Sestito, Simona; Chiarugi, S; Runfola, M; Espinoza, S; Sabatini, Martina; Bellusci, L; Laurino, A; Cichero, E; Gainetdinov, Rr; Fossa, P; Raimondi, L; Zucchi, Riccardo; Rapposelli, Simona
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 1-gen-2017 Digiacomo, Maria; Sartini, Stefania; Nesi, Giulia; Sestito, Simona; Coviello, Vito; La Motta, Concettina; Rapposelli, Simona
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 1-gen-2017 Bellusci, L; Laurino, A; Sabatini, M; Sestito, S; Lenzi, P; Raimondi, L; Rapposelli, S; Biagioni, F; Fornai, F; Salvetti, A; Rossi, L; Zucchi, R; Chiellini, G.
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 1-gen-2017 Daniele, Simona; Sestito, Simona; Pietrobono, Deborah; Giacomelli, Chiara; Chiellini, Grazia; Di Maio, Danilo; Marinelli, Luciana; Novellino, Ettore; Martini, Claudia; Rapposelli, Simona
H2S-BASED THERAPEUTIC AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 1-gen-2017 Calderone, Vincenzo; Puricelli, Guido; Rapposelli, Simona; Sestito, Simona
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 1-gen-2017 Nesi, G; Chen, Q; Sestito, S; Digiacomo, M; Yang, X; Wang, S; Pi, R; Rapposelli, S.
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 1-gen-2017 Chiellini, G.; Rapposelli, S.; Nesi, G.; Sestito, S.; Sabatini, M.; Zhu, J.; Massarelli, I.; Plum, L. A.; Clagett‐dame, M.; Deluca, H. F.
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease 1-gen-2017 Chen, Ziwei; Digiacomo, Maria; Tu, Yalin; Gu, Qiong; Wang, Shengnan; Yang, Xiaohong; Chu, Jiaqi; Chen, Qiuhe; Han, Yifan; Chen, Jingkao; Nesi, Giulia; Sestito, Simona; Macchia, Marco; Rapposelli, Simona; Pi, Rongbiao
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 1-gen-2017 Nesi, Giulia; Sestito, Simona; Digiacomo, Maria; Rapposelli, Simona
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 1-gen-2017 Sestito, Simona; Nesi, Giulia; Pi, Rongbiao; Macchia, Marco; Rapposelli, Simona
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 1-gen-2018 Sestito, Simona; Daniele, Simona; Martini, Claudia; Rapposelli, Simona; Puricelli, Guido
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