Several problems that involves brain drug delivery depend on the possibility of blood brain barrier (BBB) crossing drug molecules properties. Transcytosis is an important way to cross BBB. In this study an analytic model is realized of this kind of transport process, that should be useful to help researcher activity, according to ethical problems that involve in vivo brain studies. The obtained model is a generalization of previous models of endocytosis extended to consider the esocytosis process at the apical side of BBB endothelial cell. A set of eight differential equations is obtained, that has been simplified according to biological hypotheses. The lack of experimental datasets make difficult an exact model validation. However, kinetic constants could be extrapolated from literature data. Thanks to this model, it should be possible to predict the concentration of the selected molecule in the brain, as a function of its concentration in the plasma. This paper reports on the model definition and its implementation in the Matlab Simulink environment.

A Model of Transcytosis Processes Across the Blood Brain Barrier

LANDI, ALBERTO
2008-01-01

Abstract

Several problems that involves brain drug delivery depend on the possibility of blood brain barrier (BBB) crossing drug molecules properties. Transcytosis is an important way to cross BBB. In this study an analytic model is realized of this kind of transport process, that should be useful to help researcher activity, according to ethical problems that involve in vivo brain studies. The obtained model is a generalization of previous models of endocytosis extended to consider the esocytosis process at the apical side of BBB endothelial cell. A set of eight differential equations is obtained, that has been simplified according to biological hypotheses. The lack of experimental datasets make difficult an exact model validation. However, kinetic constants could be extrapolated from literature data. Thanks to this model, it should be possible to predict the concentration of the selected molecule in the brain, as a function of its concentration in the plasma. This paper reports on the model definition and its implementation in the Matlab Simulink environment.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/124884
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