Abstract In Flow-mediated dilation (FMD) studies, blood flow in the brachial artery is restricted for about 5 minutes by a cuff. When the restriction is removed, the subsequent increase in wall shear rate (WSR) stimulates the release of nitric oxide, a vasodilator, from the endothelial cells into the smooth muscle. Impaired FMD responses, which are considered independent predictors of possible cardiovascular events, should be reliably detected. While several efforts have been so far dedicated to measure the diameter change, the source of this change, i.e., the WSR increase, has not been measured so far. In this paper, first results of the simultaneous measurement of WSR and diameter performed during FMD studies in the brachial arteries of 15 volunteers are reported. All measurements were obtained through the ULtrasound Advanced Open Platform (ULA-OP). © 2010 IEEE. Author keywords arterial diameter measurement; Doppler; Flow-mediated dilation; wall distension; wall shear rate Indexed Keywords Arterial diameter; Doppler; Flow-mediated dilation; wall distension; Wall shear rates Engineering controlled terms: Endothelial cells; Nitric oxide; Shear deformation; Ultrasonics Engineering main heading: Shear flow ISSN: 10510117 ISBN: 978-145770382-9 CODEN: PIEUESource Type: Conference Proceeding Original language: English DOI: 10.1109/ULTSYM.2010.5935468Document Type: Conference Paper Sponsors: IEEE Ultrasonics, Ferroelectrics, and,Frequency Control Society (UFFC)

Simultaneous measurement of wall shear stress and arterial distension in FMD studies

PALOMBO, CARLO
2010-01-01

Abstract

Abstract In Flow-mediated dilation (FMD) studies, blood flow in the brachial artery is restricted for about 5 minutes by a cuff. When the restriction is removed, the subsequent increase in wall shear rate (WSR) stimulates the release of nitric oxide, a vasodilator, from the endothelial cells into the smooth muscle. Impaired FMD responses, which are considered independent predictors of possible cardiovascular events, should be reliably detected. While several efforts have been so far dedicated to measure the diameter change, the source of this change, i.e., the WSR increase, has not been measured so far. In this paper, first results of the simultaneous measurement of WSR and diameter performed during FMD studies in the brachial arteries of 15 volunteers are reported. All measurements were obtained through the ULtrasound Advanced Open Platform (ULA-OP). © 2010 IEEE. Author keywords arterial diameter measurement; Doppler; Flow-mediated dilation; wall distension; wall shear rate Indexed Keywords Arterial diameter; Doppler; Flow-mediated dilation; wall distension; Wall shear rates Engineering controlled terms: Endothelial cells; Nitric oxide; Shear deformation; Ultrasonics Engineering main heading: Shear flow ISSN: 10510117 ISBN: 978-145770382-9 CODEN: PIEUESource Type: Conference Proceeding Original language: English DOI: 10.1109/ULTSYM.2010.5935468Document Type: Conference Paper Sponsors: IEEE Ultrasonics, Ferroelectrics, and,Frequency Control Society (UFFC)
2010
9781457703829
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/141371
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact