The authors describe the synthesis of several N-(indol-3-ylglyoxylyl)methionine derivatives. The target compounds were prepared starting from substituted indoleglyoxylyl chlorides and methionine ethyl ester. Some of them were tested for their gastric anti-secretory activity. Among these compounds, the N-(5-chloroindol-3-ylglyoxylyl)methionine Ve was the most active, being quite comparable to cimetidine.
N-(Indol-3-ylglyoxylyl)methionine derivatives: preparation and gastric anti-secretory activity.
MARINI, ANNA MARIA;
1988-01-01
Abstract
The authors describe the synthesis of several N-(indol-3-ylglyoxylyl)methionine derivatives. The target compounds were prepared starting from substituted indoleglyoxylyl chlorides and methionine ethyl ester. Some of them were tested for their gastric anti-secretory activity. Among these compounds, the N-(5-chloroindol-3-ylglyoxylyl)methionine Ve was the most active, being quite comparable to cimetidine.File in questo prodotto:
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