Viburspiran (8), a structurally new member of the maleic anhydride natural products, was isolated, along with seven known compounds 9-15, from the fungal endophyte Cryptosporiopsis sp. The structure of the new compound was elucidated by spectroscopic methods and confirmed by single-crystal X-ray analysis. The absolute configuration was established by TDDFT CD calculations by using the solid-state structure for input geometry. Viburspiran (8) is the first representative of a new class of eight-membered maleic anhydride natural products, named octadrides and exhibited antifungal activity against Botrytis cinerea and Microbotryum violaceum. Viburspiran (8), the first representative of a new class of eight-membered maleicanhydride natural products, named octadrides, was isolated from the fungal endophyte Cryptosporiopsis sp. The structure was confirmed by single-crystal X-ray analysis and the absolute configuration established by TDDFT CD calculations. Viburspiran (8) exhibited antifungal activity against Botrytis cinerea and Microbotryum violaceum.
Viburspiran, an Antifungal Member of the Octadride Class of Maleic Anhydride Natural Products
PESCITELLI, GENNARO;
2011-01-01
Abstract
Viburspiran (8), a structurally new member of the maleic anhydride natural products, was isolated, along with seven known compounds 9-15, from the fungal endophyte Cryptosporiopsis sp. The structure of the new compound was elucidated by spectroscopic methods and confirmed by single-crystal X-ray analysis. The absolute configuration was established by TDDFT CD calculations by using the solid-state structure for input geometry. Viburspiran (8) is the first representative of a new class of eight-membered maleic anhydride natural products, named octadrides and exhibited antifungal activity against Botrytis cinerea and Microbotryum violaceum. Viburspiran (8), the first representative of a new class of eight-membered maleicanhydride natural products, named octadrides, was isolated from the fungal endophyte Cryptosporiopsis sp. The structure was confirmed by single-crystal X-ray analysis and the absolute configuration established by TDDFT CD calculations. Viburspiran (8) exhibited antifungal activity against Botrytis cinerea and Microbotryum violaceum.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
