The enzymatic reduction of (+/-)-2-methylcyclohexanone with fresh carrot root as biocatalyst occurred in a complete diastereoisomeric way giving a 1:1 mixture of enantiomerically pure (1S,2R)- and (1S,2S)-2-methylcyclohexanol. The analogous reaction carried out on the racemic 2-hydroxycyclohexanone afforded a 1:2 mixture of (1S,2R)- and (1S,2S)-1,2-cyclohexanediol with an enantiomeric excess > 95%. The low cost and the easy availability of the biocatalyst besides the very simple reaction conditions suggest the possible use of the present method for large scale preparations of important chiral alcohols. (C) 2000 Elsevier Science B.V. All rights reserved.

Preparative synthesis of chiral alcohols by enantioselective reduction with Daucus carota root as biocatalyst

CHIAPPE, CINZIA;
2000-01-01

Abstract

The enzymatic reduction of (+/-)-2-methylcyclohexanone with fresh carrot root as biocatalyst occurred in a complete diastereoisomeric way giving a 1:1 mixture of enantiomerically pure (1S,2R)- and (1S,2S)-2-methylcyclohexanol. The analogous reaction carried out on the racemic 2-hydroxycyclohexanone afforded a 1:2 mixture of (1S,2R)- and (1S,2S)-1,2-cyclohexanediol with an enantiomeric excess > 95%. The low cost and the easy availability of the biocatalyst besides the very simple reaction conditions suggest the possible use of the present method for large scale preparations of important chiral alcohols. (C) 2000 Elsevier Science B.V. All rights reserved.
2000
Baldassarre, F; Bertoni, G; Chiappe, Cinzia; Marioni, F.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/160171
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 75
social impact