Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H(37)Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.
Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives
MANERA, CLEMENTINA;SACCOMANNI, GIUSEPPE
1998-01-01
Abstract
Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H(37)Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
