The 7-chloro-3-(2-chlorobenzyl)- and 7-chloro-3-(2-fluorobenzyl)-1,2,3-triazolo[4,5-d]pyrimidines (1 and 4), by nucleophilic replacement with some hydrazides, gave the corresponding 7-hydrazidoderivatives (2a-e and 5a-e). These, by heating in Dowtherm, underwent an intramolecular cyclization to form the new tricyclic 7-substituted-3-(2-chlorobenzyl)- and 3-(2-fluorobenzyl)-1,2,3-triazolo[4,5-e]1,2,4-triazolo[4,3-c]pyrimidines (3a-d and 6a-d). The 7-hydrazino-3-(2-chlorobenzyl)- and 7-hydrazino-3-(2-fluorobenzyl)-triazolo-pyrimidines (9a and 9b) were also prepared via the corresponding mercapto (7a and 7b) and thiomethyl (8a and 8b) derivatives.

NEW 1,2,3-TRIAZOLO[4,5-E]1,2,3-TRIAZOLO[4,3-C]PYRIMIDINE DERIVATIVES.II

GIORGI, IRENE;
2002-01-01

Abstract

The 7-chloro-3-(2-chlorobenzyl)- and 7-chloro-3-(2-fluorobenzyl)-1,2,3-triazolo[4,5-d]pyrimidines (1 and 4), by nucleophilic replacement with some hydrazides, gave the corresponding 7-hydrazidoderivatives (2a-e and 5a-e). These, by heating in Dowtherm, underwent an intramolecular cyclization to form the new tricyclic 7-substituted-3-(2-chlorobenzyl)- and 3-(2-fluorobenzyl)-1,2,3-triazolo[4,5-e]1,2,4-triazolo[4,3-c]pyrimidines (3a-d and 6a-d). The 7-hydrazino-3-(2-chlorobenzyl)- and 7-hydrazino-3-(2-fluorobenzyl)-triazolo-pyrimidines (9a and 9b) were also prepared via the corresponding mercapto (7a and 7b) and thiomethyl (8a and 8b) derivatives.
2002
Biagi, G; Giorgi, Irene; O., Livi; F., Pacchini; V., Scartoni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/187817
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