Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.

Developmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians

FIERABRACCI, VANNA;FRANZINI, MARIA;BAGGIANI, ANGELO;FORNACIARI, IRENE;POMPELLA, ALFONSO;PAOLICCHI, ALDO
2012-01-01

Abstract

Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.
2012
Fierabracci, Vanna; Franzini, Maria; Baggiani, Angelo; Fornaciari, Irene; Burchielli, S; Urciuoli, P; Lamanna, R; Lapi, S; Nocchi, F; Iorio, Mc; Emdin, Michele; Pompella, Alfonso; Paolicchi, Aldo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/188810
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