Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.

Could age modify the effect of genetic variants in IL6 and TNF-a genes in multiple myeloma?

BUDA, GABRIELE;MAGGINI, VALENTINA;GALIMBERTI, SARA;BARALE, ROBERTO;PETRINI, MARIO;ROSSI, ANNA MARIA
2012-01-01

Abstract

Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
2012
Martino, A; Buda, Gabriele; Maggini, Valentina; Lapi, F; Lupia, A; Di Bello, D; Orciuolo, E; Galimberti, Sara; Barale, Roberto; Petrini, Mario; Rossi, ANNA MARIA
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/188890
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