From the roots of Vismia guineensis 23 structurally related compounds were isolated and identified. Ten of them are new constituents, namely 3-O- (2-hydroxy-3-methylbut-3-enyl)-emodin (1); 3-O-(2-methoxy-3-methylbut-3- enyl)-emodin (2); 1,8-dihydroxy-3-(2-methoxy-3-methylbut-3-enyloxy)-6- methylxanthone (3); 1,8-dihydroxy-3-geranyloxy-6-methylxanthone (4); 1,8- dihydroxy-3-isoprenyloxy-6-methylxanthone (5); 1,8-dihydroxy-3-(3,7-dimethyl- 7-methoxyoct-2-enyloxy)-6-methylxanthone (6); 3-O-(E-3-hydroxymethylbut-2- enyl)-emodin (7); 3-O-(3-hydroxymethyl-4-hydroxybut-2-enyl)-emodin (8); 1,8- dihydroxy-3-(E-3-hydroxymethylbut-2-enyloxy)-6-methylxanthone (9); and 1,8- dihydroxy-3-(3-hydroxymethyl-4-hydroxybut-2-enyloxy)-6-methylxanthone (10). Their structures were established by means of EIMS and a combination of homonuclear and heteronuclear 2D NMR techniques. Furthermore, an in vitro preliminary screening of antimitotic activity of all the isolated compounds was also evaluated.
New prenylated Quinones from Vismia guineensis
BRACA, ALESSANDRA;MORELLI, IVANO
2000-01-01
Abstract
From the roots of Vismia guineensis 23 structurally related compounds were isolated and identified. Ten of them are new constituents, namely 3-O- (2-hydroxy-3-methylbut-3-enyl)-emodin (1); 3-O-(2-methoxy-3-methylbut-3- enyl)-emodin (2); 1,8-dihydroxy-3-(2-methoxy-3-methylbut-3-enyloxy)-6- methylxanthone (3); 1,8-dihydroxy-3-geranyloxy-6-methylxanthone (4); 1,8- dihydroxy-3-isoprenyloxy-6-methylxanthone (5); 1,8-dihydroxy-3-(3,7-dimethyl- 7-methoxyoct-2-enyloxy)-6-methylxanthone (6); 3-O-(E-3-hydroxymethylbut-2- enyl)-emodin (7); 3-O-(3-hydroxymethyl-4-hydroxybut-2-enyl)-emodin (8); 1,8- dihydroxy-3-(E-3-hydroxymethylbut-2-enyloxy)-6-methylxanthone (9); and 1,8- dihydroxy-3-(3-hydroxymethyl-4-hydroxybut-2-enyloxy)-6-methylxanthone (10). Their structures were established by means of EIMS and a combination of homonuclear and heteronuclear 2D NMR techniques. Furthermore, an in vitro preliminary screening of antimitotic activity of all the isolated compounds was also evaluated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.