The chronic use of methamphetamine leads to cardiomyopathy and a nigrostriatal dopamine deficiency that partly mimics what occurs in Parkinson's disease. This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or during the course of Parkinson's disease.
|Autori:||RUFFOLI R; SOLDANI P; PASQUALI L; RUGGIERI S; PAPARELLI A; FORNAI F|
|Titolo:||Methamphetamine fails to alter the noradrenergic integrity of the heart|
|Anno del prodotto:||2008|
|Digital Object Identifier (DOI):||10.1196/annals.1432.017|
|Appare nelle tipologie:||1.1 Articolo in rivista|