The rabbit liver epoxide hydrolase contained in the microsomal fraction (mEH) has been checked for its enantioselectivity towards several racemic ortho-, meta-, and para-substituted phenyloxiranes, benzyloxirane, and phenoxymethyloxirane. While for the last two substrates non-selective hydrolysis is observed, the orientation of substituents on the benzene ring is found to affect significantly the selective ring opening of phenyloxiranes.
ENANTIOSELECTIVE HYDROLYSIS OF SUBSTITUTED PHENYLOXIRANES BY RABBIT LIVER MICROSOMAL EPOXIDE HYDROLASE
CHIAPPE, CINZIA;
1992-01-01
Abstract
The rabbit liver epoxide hydrolase contained in the microsomal fraction (mEH) has been checked for its enantioselectivity towards several racemic ortho-, meta-, and para-substituted phenyloxiranes, benzyloxirane, and phenoxymethyloxirane. While for the last two substrates non-selective hydrolysis is observed, the orientation of substituents on the benzene ring is found to affect significantly the selective ring opening of phenyloxiranes.File in questo prodotto:
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