The aim of this study was to evaluate the early effects of high and low-osmolar contrast media on glomerular function in rats by using a new method based on the measurement of the urinary excretion of Tc-99m-DTPA. Thirty-six Sprague-Dawley male rats were examined: nine rats were injected with diatrizoate (ionic high-osmolar contrast medium), nine rats with iohexol (nonionic low-osmolar contrast medium), nine rats with iopamidol (nonionic low-osmolar contrast medium), and nine rats with saline as controls. The urinary excretion of Tc-99m-DTPA in the first minutes after i.v. injection was assumed as an index of glomerular filtration rate. A lower urinary excretion of Tc-99m-DTPA was found in rats treated with contrast media in comparison with control rats. This effect was more evident after diatrizoate but was statistically significant also after iohexol. In conclusion, a reduction in the glomerular filtration rate probably occurs in the first few minutes after contrast media administration. The measurement of urinary excretion of Tc-99m-DTPA could be a simple method to detect acute glomerular effects due to contrast media or to other drugs.
Early glomerular effects of contrast media in rats: evaluation with a simple methods
DONADIO, CARLO;TRAMONTI, GIANFRANCO;
1998-01-01
Abstract
The aim of this study was to evaluate the early effects of high and low-osmolar contrast media on glomerular function in rats by using a new method based on the measurement of the urinary excretion of Tc-99m-DTPA. Thirty-six Sprague-Dawley male rats were examined: nine rats were injected with diatrizoate (ionic high-osmolar contrast medium), nine rats with iohexol (nonionic low-osmolar contrast medium), nine rats with iopamidol (nonionic low-osmolar contrast medium), and nine rats with saline as controls. The urinary excretion of Tc-99m-DTPA in the first minutes after i.v. injection was assumed as an index of glomerular filtration rate. A lower urinary excretion of Tc-99m-DTPA was found in rats treated with contrast media in comparison with control rats. This effect was more evident after diatrizoate but was statistically significant also after iohexol. In conclusion, a reduction in the glomerular filtration rate probably occurs in the first few minutes after contrast media administration. The measurement of urinary excretion of Tc-99m-DTPA could be a simple method to detect acute glomerular effects due to contrast media or to other drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
