A series of hydrogenated isoindolone derivatives structurally related to cytochalasin B has been synthesized and their ability to induce binucleation in the human lymphocytes were tested. All compounds were found able to inhibit cell cytokinesis at different extent in the range (3.12-25 μmol/l) respect to the negative control; however the highest percentage of binucleated cells is induced by Cyt B.
Synthesis and biological activity of a series of isoindolone derivatives related to cytochalasins
PISTELLI, LUISA;MIGLIORE, LUCIA;
1996-01-01
Abstract
A series of hydrogenated isoindolone derivatives structurally related to cytochalasin B has been synthesized and their ability to induce binucleation in the human lymphocytes were tested. All compounds were found able to inhibit cell cytokinesis at different extent in the range (3.12-25 μmol/l) respect to the negative control; however the highest percentage of binucleated cells is induced by Cyt B.File in questo prodotto:
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