The use of platinum-catalyzed hydrosilylation chemistry of silicones greatly simplifies the preparation of bis-oxazoline (box) ligands covalently bound to an insoluble polymeric support. The use of such immobilized chiral ligands in different copper-catalyzed asymmetric transformations (carbonyl-ene, Mukaiyama aldol and olefin cyclopropanation reactions) allows the attainment of high levels of enantioselectivity (91-99 % ee).
Remarkable Efficiency Improvement in the Preparation of Insoluble Polymer-Bound (IPB) Enantioselective Catalytic Systems by the Use of Silicone Chemistry
MANDOLI, ALESSANDRO;LESSI, MARCO;PINI, DARIO;SALVADORI, PIERO
2008-01-01
Abstract
The use of platinum-catalyzed hydrosilylation chemistry of silicones greatly simplifies the preparation of bis-oxazoline (box) ligands covalently bound to an insoluble polymeric support. The use of such immobilized chiral ligands in different copper-catalyzed asymmetric transformations (carbonyl-ene, Mukaiyama aldol and olefin cyclopropanation reactions) allows the attainment of high levels of enantioselectivity (91-99 % ee).File in questo prodotto:
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