Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmethyloxy)beta-alanines (D) were synthesised and tested as aldose reductase inhibitors (ARIs). Compounds C and D differ from the previously reported ARIs of type A in the presence of a further CH2 spacer between the aryl moiety and the oxyamidic oxygen and between the oxyamidic nitrogen and the carboxyl group. Compounds C revealed a certain loss of inhibitory activity with respect to the corresponding type A derivatives. Compounds D were found to be devoid of any appreciable inhibitory activity.
Synthesis and aldose reductase inhibitory activity of some N-(aroyl)-N-(arylalkyloxy)-glycines and -beta-alanines
MACCHIA, MARCO;NENCETTI, SUSANNA;ORLANDINI, ELISABETTA;ROSSELLO, ARMANDO
1996-01-01
Abstract
Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmethyloxy)beta-alanines (D) were synthesised and tested as aldose reductase inhibitors (ARIs). Compounds C and D differ from the previously reported ARIs of type A in the presence of a further CH2 spacer between the aryl moiety and the oxyamidic oxygen and between the oxyamidic nitrogen and the carboxyl group. Compounds C revealed a certain loss of inhibitory activity with respect to the corresponding type A derivatives. Compounds D were found to be devoid of any appreciable inhibitory activity.File in questo prodotto:
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