Objectives: To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. Design and methods: The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV serostatus was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. Results: Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. Conclusions: These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.

HIV-1 TRANSMISSION THROUGH BREAST-MILK - APPRAISAL OF RISK ACCORDING TO DURATION OF FEEDING

CONSOLINI, RITA
1992-01-01

Abstract

Objectives: To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. Design and methods: The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV serostatus was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. Results: Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. Conclusions: These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.
1992
De, Martino; M, Tovo; Pa, Tozzi; Ae, Pezzotti; P, Galli; L, Livadiotti; S, Caselli; D, Massironi; E, Ruga; E, Fioredda; F, Plebani; A, Gabiano; C, Zuccotti; Other partecipants in the Italian Register for HIV Infection in Children, Gv; Conte, A; Rizzi, M; Mazzoni, Pl; Ibba, P; Ferraris, G; Benaglia, G; Stegagno, M; Masi, M; Dallacasa, P; Duse, M; Rossi, G; Sciotto, A; Barbanera, M; De, Mattai; D, Zaniboni; Mg, Bezzi; T, Campelli; A, Ciccimarra; F, Bassanetti; F, ; Consolini, Rita
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/20267
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