The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 mu M was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [H-3]dopamine uptake. Moreover, DDC 1 mu M greatly potentiated cell death induced by glutamate 10 and 50 mu M. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.

Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures

VAGLINI, FRANCESCA;PARDINI, CARLA MARIA FRANCESCA;
1995-01-01

Abstract

The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 mu M was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [H-3]dopamine uptake. Moreover, DDC 1 mu M greatly potentiated cell death induced by glutamate 10 and 50 mu M. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.
1995
Vaglini, Francesca; Pardini, CARLA MARIA FRANCESCA; Maggio, R.; Corsini, G. U.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/21182
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