The activity of Aminosidine/N-methylglucamine antimoniate combination vs. N-methylglucamine antimoniate was evaluated in 20 dogs naturally infected with Leishmania infantum. Fifteen dogs were treated with an association of Amminofarma (0.6 ml/10 kg) and Glucantim (60 mg/kg) (Group 1), while 5 control animals were treated with 100 mg/kg of Glucantim (Group 2). All the drugs were administered subcutaneously, twice a day for two cycles of 21 days intervalled by a 10 days interruption. The Aminosidine/N-methylglucamine antimoniate combination yielded marked decrease of anti-Leishmania antibodies. Clinical cure was obtained in all the subjects of the Group 1 and only in 3 out of 5 of the Group 2. the drugs' combination was effective also in reducing the level of the serum proteins.
Valutazione dell'efficacia dell'associazione amminosidina (Amminofarma TM)-antimonio (Glucantim TM) rispetto al solo antimonio nella terapia della leishmaniosi canina
MANCIANTI, FRANCESCA;PEDONESE, FRANCESCA;
1998-01-01
Abstract
The activity of Aminosidine/N-methylglucamine antimoniate combination vs. N-methylglucamine antimoniate was evaluated in 20 dogs naturally infected with Leishmania infantum. Fifteen dogs were treated with an association of Amminofarma (0.6 ml/10 kg) and Glucantim (60 mg/kg) (Group 1), while 5 control animals were treated with 100 mg/kg of Glucantim (Group 2). All the drugs were administered subcutaneously, twice a day for two cycles of 21 days intervalled by a 10 days interruption. The Aminosidine/N-methylglucamine antimoniate combination yielded marked decrease of anti-Leishmania antibodies. Clinical cure was obtained in all the subjects of the Group 1 and only in 3 out of 5 of the Group 2. the drugs' combination was effective also in reducing the level of the serum proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
