Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth factor receptor (EGFR)-T790M mutation, have been reported1; these patients had family histories of lung cancer. The activity of gefitinib was tested in only two patients, who were both refractory to this drug.2 Herein, we describe a family of European descent in which two family members had non-small cell lung cancer associated with germline transmission of T790M mutation and who were treated with gefitinib.

Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients

BOLDRINI, LAURA;DANESI, ROMANO;FONTANINI, GABRIELLA
2011-01-01

Abstract

Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth factor receptor (EGFR)-T790M mutation, have been reported1; these patients had family histories of lung cancer. The activity of gefitinib was tested in only two patients, who were both refractory to this drug.2 Herein, we describe a family of European descent in which two family members had non-small cell lung cancer associated with germline transmission of T790M mutation and who were treated with gefitinib.
2011
C., Tibaldi; E., Giovannetti; E., Vasile; Boldrini, Laura; M. I., Gallegos Ruiz; I., Bernardini; R., Incensati; Danesi, Romano; F., Cappuzzo; G. J., Peters; Fontanini, Gabriella
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/237204
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