FlY is a newly discovered lentivirus isolated from domestic cats with an acquired immunodeficiency syndrome-like condition. Unspecified renal abnormalities were reported in some infected cats. In the present report morphological and clinical aspects of the nephropathy observed in cats naturally infected with FlY are described in detail. Fifteen FIV-infected cats were examined: they included 11 males and four females ranging in age from 3.5 to 13 years. Proteinuria was present in 14 of 15 cats (>1 g/liter in 7 animals). BUN values were greater than normal in 11 cats (80 to 327 mg/dl vs. 20 to 65 mg/dl); eight of these had increased serum creatinine values (1.7 to 3.2 mg/dl vs. l.6 mg/dl). At necropsy, blocks of renal tissue were collected for histological, ultrastructural and IF studies. Renal tissue damage was evident in 12 of 15 animals. It included glomerular lesions (consisting of a diffuse increase of mesangial matrix and/or a focal and segmental sclerosis) as well as tubulointerstitial lesions (consisting of focal tubular degenerative changes, focal tubular ectasia, prominent interstitial inflammation of lymphocytes and plasma cells and occasional interstitial fibrosis). Glomeruli were positive for 1gM and C3, with coarsely granular deposits in mesangium and in a few peripheral capillary walls. Our findings demonstrated that naturally Fl V-infected cats may have renal disorders that share considerable features with HIV-related nephropathy. Thus, FIV-infected cats may also represent a useful animal model for this aspect of HIV-induced pathology.
Feline Immunodeficiency virus (FIV)-associated nephropathy in domestic cats: An animal model of HIV-nephropathy
ABRAMO, FRANCESCA;TACCINI, ENNIO;POLI, ALESSANDRO;MALVALDI, GINO;BENDINELLI, MAURO
1993-01-01
Abstract
FlY is a newly discovered lentivirus isolated from domestic cats with an acquired immunodeficiency syndrome-like condition. Unspecified renal abnormalities were reported in some infected cats. In the present report morphological and clinical aspects of the nephropathy observed in cats naturally infected with FlY are described in detail. Fifteen FIV-infected cats were examined: they included 11 males and four females ranging in age from 3.5 to 13 years. Proteinuria was present in 14 of 15 cats (>1 g/liter in 7 animals). BUN values were greater than normal in 11 cats (80 to 327 mg/dl vs. 20 to 65 mg/dl); eight of these had increased serum creatinine values (1.7 to 3.2 mg/dl vs. l.6 mg/dl). At necropsy, blocks of renal tissue were collected for histological, ultrastructural and IF studies. Renal tissue damage was evident in 12 of 15 animals. It included glomerular lesions (consisting of a diffuse increase of mesangial matrix and/or a focal and segmental sclerosis) as well as tubulointerstitial lesions (consisting of focal tubular degenerative changes, focal tubular ectasia, prominent interstitial inflammation of lymphocytes and plasma cells and occasional interstitial fibrosis). Glomeruli were positive for 1gM and C3, with coarsely granular deposits in mesangium and in a few peripheral capillary walls. Our findings demonstrated that naturally Fl V-infected cats may have renal disorders that share considerable features with HIV-related nephropathy. Thus, FIV-infected cats may also represent a useful animal model for this aspect of HIV-induced pathology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
