Patients with atherosclerosis and/or hypertension exhibit both endothelial dysfunction and impaired insulin action. However, no direct association between insulin resistence and endothelial dysfunction was demonstrated. To evaluate this relation, the transcapillary escape of albumin (TERalb), influenced by endothelium, extracellular matrix properties and by haemodinamic forces, and insulin resistance assessed by the homeostasis model (HOMA) were measured in 96 nondiabetic males: 23 healthy controls (C), 37 essential hypertensives (EH), 23 atherosclerotic subjects (ATH) and 13 hypertensive-atherosclerotic ones (EH/ATH). The four groups were similar for age, serum creatinine and fibrinogen. BMI was lightly higher in EH and EH/ATH (p=0.004). Atherosclerotic groups (ATH,EH/ATH) had higher total- and LDL-cholesterol levels (p<0.005), ApoB (p<O.OI), triglycerides (p=0.02) compared with C and EH. Systolic and diastolic 24 hour ambulatory BP were significantly higher (p=0.0001) in EH and EH/ATH, and similar in C and ATH. Urinary albumin excretion (logAER) was higher in EH/ATH (159±73 μg/mnin; M±SE), but similar in C (8.8±2.0), EH (12.9±2.3) and ATH (7.5±0.8) (p=0.0001). Serum albumin, haematocrit, plasma volume and intravascular mass of albumin did not differ in the four groups. Serum albumin and haematocrit were stable in each subject in the TERalb test. TERalb was 6.5±1.6 %/h in controls and higher (logTERalb, p=0.0001) in EH (9.1±2.6, p<0.01), ATH (10.2±2.6, p<0.001) and EH/ATH (10.4±3.3, p<0.001). HOMA IR was 2.0±0.20 in controls and higher (p=0.07) in EH (2.65±0.22), ATH (2.33±0.31) and EH/ATH (2.54±0.32). Positive linear regression was found between TERalb and BMI (r=0.23, p=0.024). Stepwise regression showed that (model 1) presence of atherosclerosis (r=0.393), hypertension (cumulative r=0.521) and BMI (r=0.546), and (model2) atherosclerosis (r=0.337), hypertension(r=0.421) and HOMA IR (r=0.439), independently contribute to TERalb variability. These data suggest a relation between widespread endothelial dysfunction and insulin action and provide further evidence for a relation with one of the main features (increased body weight) of the insulin resistance syndrome.

Insulin Resistance and endothelial dysfunction in hypertensive and atherosclerotic non diabetic subjects

PEDRINELLI, ROBERTO;PENNO G.
1998-01-01

Abstract

Patients with atherosclerosis and/or hypertension exhibit both endothelial dysfunction and impaired insulin action. However, no direct association between insulin resistence and endothelial dysfunction was demonstrated. To evaluate this relation, the transcapillary escape of albumin (TERalb), influenced by endothelium, extracellular matrix properties and by haemodinamic forces, and insulin resistance assessed by the homeostasis model (HOMA) were measured in 96 nondiabetic males: 23 healthy controls (C), 37 essential hypertensives (EH), 23 atherosclerotic subjects (ATH) and 13 hypertensive-atherosclerotic ones (EH/ATH). The four groups were similar for age, serum creatinine and fibrinogen. BMI was lightly higher in EH and EH/ATH (p=0.004). Atherosclerotic groups (ATH,EH/ATH) had higher total- and LDL-cholesterol levels (p<0.005), ApoB (p
1998
https://link.springer.com/article/10.1007/BF03192011
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/49474
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact