The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues.

An efficient substitution reaction for the preparation of thyroid hormone analogues

CHIELLINI, GRAZIA;
1998-01-01

Abstract

The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues.
1998
Yoshihara, Hai; Chiellini, Grazia; Mitchison, Tj; Scanlan, Ts
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/50741
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