Aims. (i) To analyze the in vivo corneal structure and sub-basal plexus nerves in patients with primary Sjögren's syndrome (pSS) and no-SS dry eye by confocal scanning laser microscopy (CSLM) and (ii) to correlate CSLM findings with tear function tests and with patients' subjective dryness. Methods. Seventeen patients with pSS, 16 no-SS dry eye, and 20 healthy volunteers were included. CSLM parameters taken into consideration included: basal epithelial integrity, corneal thickness, epithelial cellular density, keratocyte activation, and sub-basal plexus morphology. Statistical analysis was carried out using SPSS-13 (Chicago IL, USA). Results. CSLM pachymetric data and the superficial epithelium cell density were significantly lower in pSS versus no-SS dry eye (p < 0.0001); keratocyte activation and sub-basal nerve abnormalities were also more frequent in pSS patients (p < 0.0001). CSLM findings well correlated with both the ocular test results and the patients' perception of ocular dryness at the baseline and over the follow-up. Conclusion. CSLM might be a useful novel tool in the assessment of the involvement of the lachrymal functional unit in pSS.
|Autori interni:||MOSCA, MARTA|
|Autori:||G. Gabbriellini;C. Baldini;V. Varanini;C. Notarstefano;P. Pepe;F. Fanucci;F. Ferro;N. Luciano;M. Mosca;M. Nardi;S. Bombardieri|
|Titolo:||In vivo confocal scanning laser microscopy in patients with primary Sjögren's syndrome: A monocentric experience.|
|Anno del prodotto:||2014|
|Digital Object Identifier (DOI):||10.3109/14397595.2014.979523|
|Appare nelle tipologie:||1.1 Articolo in rivista|