Trichinellosis is a worldwide zoonosis caused by the parasitic nematodes belonging to the Trichinella genus. In this review we describe some aspects of the host immunity to the different species of Trichinella in humans, as well as in rodents which are one of the most studied experimental models. The role of humoral (antibodies) and cellular (T cells, mast cells, eosinophils and neutrophils), immune responses to this nematode will be considered in experimental as well as in human infections. Particular attention will be paid on the possibility to exploit such knowledge to improve the diagnostic possibilities of infection. Immunopathological aspects of infection will also be considered. Finally, the evasion mechanisms of host immune responses exploited by Trichinella and the vaccination perspectives for control will be elucidated.

The translational immunology of trichinellosis: from rodents to humans.

BRUSCHI, FABRIZIO;
2014-01-01

Abstract

Trichinellosis is a worldwide zoonosis caused by the parasitic nematodes belonging to the Trichinella genus. In this review we describe some aspects of the host immunity to the different species of Trichinella in humans, as well as in rodents which are one of the most studied experimental models. The role of humoral (antibodies) and cellular (T cells, mast cells, eosinophils and neutrophils), immune responses to this nematode will be considered in experimental as well as in human infections. Particular attention will be paid on the possibility to exploit such knowledge to improve the diagnostic possibilities of infection. Immunopathological aspects of infection will also be considered. Finally, the evasion mechanisms of host immune responses exploited by Trichinella and the vaccination perspectives for control will be elucidated.
2014
Bruschi, Fabrizio; Gomez Morales, M. A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/668466
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact