Recent evidence indicates an involvement of P2X7 purinergic receptor (P2X7R) in the fine tuning of immune functions, as well as in driving enteric neuron apoptosis under intestinal inflammation. However, the participation of this receptor in the regulation of enteric neuromuscular functions remains undetermined. This study was aimed at investigating the role of P2X7Rs in the control of colonic motility in experimental colitis.
Involvement of the P2X7 purinergic receptor in colonic motor dysfunction associated with bowel inflammation in rats
ANTONIOLI, LUCA;PELLEGRINI, CAROLINA;TUCCORI, MARCO;BLANDIZZI, CORRADO;FORNAI, MATTEO
2014-01-01
Abstract
Recent evidence indicates an involvement of P2X7 purinergic receptor (P2X7R) in the fine tuning of immune functions, as well as in driving enteric neuron apoptosis under intestinal inflammation. However, the participation of this receptor in the regulation of enteric neuromuscular functions remains undetermined. This study was aimed at investigating the role of P2X7Rs in the control of colonic motility in experimental colitis.File in questo prodotto:
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ANTONIOLI-GIRON-COLUC.INVOLV P2X7-2014-PLOSONE.pdf
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