The present invention relates to synthesis of a series of rivastigmine derivatives, wherein the structural formula is represented by a formula (I). According to the present invention, with the substituent changing, the inhibition of acetylcholine/butyrylcholine esterase by adjusting the rivastigmine derivatives, the inhibition of glutamic acid-induced oxidative stress, the reduction of damage of H2O2 and other ROS on HT22 cells, the inhibition of beta-amyloid protein self-aggregation, and the clearing of DPPH free radicals, the rivastigmine derivatives can simultaneously act on multiple targets. The rivastigmine derivatives can be made into the suitable pharmaceutical dosage form for Alzheimer's disease treatment.
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof
RAPPOSELLI, SIMONA;DIGIACOMO, MARIA;MACCHIA, MARCO;
2015-01-01
Abstract
The present invention relates to synthesis of a series of rivastigmine derivatives, wherein the structural formula is represented by a formula (I). According to the present invention, with the substituent changing, the inhibition of acetylcholine/butyrylcholine esterase by adjusting the rivastigmine derivatives, the inhibition of glutamic acid-induced oxidative stress, the reduction of damage of H2O2 and other ROS on HT22 cells, the inhibition of beta-amyloid protein self-aggregation, and the clearing of DPPH free radicals, the rivastigmine derivatives can simultaneously act on multiple targets. The rivastigmine derivatives can be made into the suitable pharmaceutical dosage form for Alzheimer's disease treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
