Microorganisms universally attach to surface and produce extracellular matrix of polysaccharidic nature termed slime. This phenomenon is now regularly referred to as biofilm formation. Biofilm-associated infections pose a serious problem for public health because bacteria growing in a biofilm are more recalcitrant to the action of antibiotics and host defenses than cells growing in a planktonic state. In orthopedic surgery, such proprieties of biofilm made prosthesis-associated infection a devastating complication. In such a “war,” the prevention with adequate pharmacological prophylaxis, pathogen-specific treatment, and the combination antimicrobial regimens are of paramount importance. The better knowledge in PJI pathogenesis and biofilm formation, reached in these last years, is a new weapon in the armamentarium of physicians.

The Fight Against the Slime: Can We Ever Win?

PIOLANTI, NICOLA;LISANTI, MICHELE;ANDREANI, LORENZO;PARCHI, PAOLO DOMENICO;MENICHETTI, FRANCESCO
2015-01-01

Abstract

Microorganisms universally attach to surface and produce extracellular matrix of polysaccharidic nature termed slime. This phenomenon is now regularly referred to as biofilm formation. Biofilm-associated infections pose a serious problem for public health because bacteria growing in a biofilm are more recalcitrant to the action of antibiotics and host defenses than cells growing in a planktonic state. In orthopedic surgery, such proprieties of biofilm made prosthesis-associated infection a devastating complication. In such a “war,” the prevention with adequate pharmacological prophylaxis, pathogen-specific treatment, and the combination antimicrobial regimens are of paramount importance. The better knowledge in PJI pathogenesis and biofilm formation, reached in these last years, is a new weapon in the armamentarium of physicians.
2015
Piolanti, Nicola; Lisanti, Michele; Andreani, Lorenzo; Parchi, PAOLO DOMENICO; Tagliaferri, Enrico; Menichetti, Francesco
File in questo prodotto:
File Dimensione Formato  
2014 Bozza Capitolo Libro Infezioni.pdf

solo utenti autorizzati

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 445.45 kB
Formato Adobe PDF
445.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/814971
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact