Smoking reduction in smokers complUmt to a smoking cessation trial with nicotine patch. E. FonuU, M. Desideri, F. PisteUi,L Carrow, R. Puntoni, S. Avina, G. GustlJvsson, U. Sawe, G. Viegi, C. Giuntini. Tbeaim of this retrospective analysis was to assess the extent of smoking reduction in smokers who were compli. ant to a smoking cessation trial with nicotine patch, and failed to completely quit smoking. Out of 297 smokers in total, 237 participants received active treatment (60 received placebo). Eighty treated subjects attended all the scheduled visits and were classjfied as either abstainers (nonsmokers), r~ smokers or occa· sional smokers. Compared to the remaining 157 participants, these 80 subjects had significantly lower mean baseline daily cigarette consumption (24 versus 30; p<o.OOI), expired carbon monoxide levels (25 versus 33 ppm; p<O.OOl), plasma nicotine and cotinine levels, and Fagerstrom Tolerance Questionnaire score (5.7 versus 7.0; p<O.OOl). All subjects received active treatment for up to 18 weeks (full dose for 12 weeks plus tapering dose for 6 weeks), with follow· up visits scheduled up to 1 yr. A statistically significant reduction in cigarette consumption (versus ba,seIine) was observed among both the occasional (·99%) and regular (·77%) smokers between week 1 and week 52 (p<O.OOl). Concomitant smoking and patch use was weD tolerated since adverse events were infrequent, mild and transient. Thus, in addition to those subjects who successfully quit smoking, a further group of subjects who attended all the foHow-up visits during the smoking cessation trial significantly reduced their mean daily cigarette consumption.

Smoking reduction in smokers compliant to a smoking cessation trial with nicotine patch

Pistelli, F;CARROZZI, LAURA;VIEGI, GIOVANNI;GIUNTINI, CARLO
2001-01-01

Abstract

Smoking reduction in smokers complUmt to a smoking cessation trial with nicotine patch. E. FonuU, M. Desideri, F. PisteUi,L Carrow, R. Puntoni, S. Avina, G. GustlJvsson, U. Sawe, G. Viegi, C. Giuntini. Tbeaim of this retrospective analysis was to assess the extent of smoking reduction in smokers who were compli. ant to a smoking cessation trial with nicotine patch, and failed to completely quit smoking. Out of 297 smokers in total, 237 participants received active treatment (60 received placebo). Eighty treated subjects attended all the scheduled visits and were classjfied as either abstainers (nonsmokers), r~ smokers or occa· sional smokers. Compared to the remaining 157 participants, these 80 subjects had significantly lower mean baseline daily cigarette consumption (24 versus 30; p
2001
Fornai, E; Desideri, M; Pistelli, F; Carrozzi, Laura; Puntoni, R; Avino, S; Gustavsson, G; Säwe, U; Viegi, Giovanni; Giuntini, Carlo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/815470
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