The present study assessed the feto-maternal calcium metabolism evaluating calciotropic hormones during pregnancy, during lactation and in cord blood. During pregnancy ionized calcium, phosphorus, intact parathyroid hormone (PTH-I), mid-molecule parathyroid hormone (PTH-MM) and 25-hydroxyvitamin D (25-OH-D) did not show any variation in respect to non pregnant healthy women. In pregnancy osteocalcin values were significantly (p < 0.05) lower in comparison with non pregnant women. Moreover, we found a significant (p < 0.001) increase of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels in the first trimester of pregnancy. Lactating mothers had normal levels of ionized calcium, phosphorus, PTH-MM and 25-OH-D; osteocalcin was significantly higher than in non lactating mothers (p < 0.001) and in pregnant (p < 0.001) and non pregnant women (p < 0.01). During lactation 1,25(OH)2D concentrations did not vary in respect to pregnancy, whereas in non lactating mothers 1,25(OH)2D values significantly (p < 0.001) falled at third post-partum day. In cord blood ionized calcium and phosphorus levels were significantly (respectively p < 0.001) and p < 0.02) higher in comparison with the values observed in pregnant women, in lactating and non lactating mothers and in non pregnant women. Osteocalcin values in cord were significantly (p < 0.001) higher in respect to those in the mothers during pregnancy. In cord, PTH-I and PTH-MM were significantly (p < 0.001) lower than those of pregnant and non pregnant women as well as of lactating and non lactating mothers. 25-OH-D and 1,25(OH)2D levels were significantly (p < 0.001) lower in cord than in maternal blood. Maternal and fetal 25-OH-D and 1,25(OH)2D concentrations were closely related. Cord 25-OH-D and 1,25(OH)2D levels showed a significant (p < 0.001) reduction in respect to those in lactating and non lactating mothers and in non pregnant women too. Our results demonstrate that feto-maternal calcium metabolism is tightly related. Increased 1,25(OH)2D levels during pregnancy and lactation might be the maternal response to maintain an adequate supply via the placenta and via breast-milk. Mineral supply and vitamin D fetal status are providing by calcium, phosphorus and 25-OH-D placental tranfer.
REGULATION OF FETOMATERNAL CALCIUM-METABOLISM
SAGGESE, GIUSEPPE;BOLDRINI, ANTONIO;
1990-01-01
Abstract
The present study assessed the feto-maternal calcium metabolism evaluating calciotropic hormones during pregnancy, during lactation and in cord blood. During pregnancy ionized calcium, phosphorus, intact parathyroid hormone (PTH-I), mid-molecule parathyroid hormone (PTH-MM) and 25-hydroxyvitamin D (25-OH-D) did not show any variation in respect to non pregnant healthy women. In pregnancy osteocalcin values were significantly (p < 0.05) lower in comparison with non pregnant women. Moreover, we found a significant (p < 0.001) increase of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels in the first trimester of pregnancy. Lactating mothers had normal levels of ionized calcium, phosphorus, PTH-MM and 25-OH-D; osteocalcin was significantly higher than in non lactating mothers (p < 0.001) and in pregnant (p < 0.001) and non pregnant women (p < 0.01). During lactation 1,25(OH)2D concentrations did not vary in respect to pregnancy, whereas in non lactating mothers 1,25(OH)2D values significantly (p < 0.001) falled at third post-partum day. In cord blood ionized calcium and phosphorus levels were significantly (respectively p < 0.001) and p < 0.02) higher in comparison with the values observed in pregnant women, in lactating and non lactating mothers and in non pregnant women. Osteocalcin values in cord were significantly (p < 0.001) higher in respect to those in the mothers during pregnancy. In cord, PTH-I and PTH-MM were significantly (p < 0.001) lower than those of pregnant and non pregnant women as well as of lactating and non lactating mothers. 25-OH-D and 1,25(OH)2D levels were significantly (p < 0.001) lower in cord than in maternal blood. Maternal and fetal 25-OH-D and 1,25(OH)2D concentrations were closely related. Cord 25-OH-D and 1,25(OH)2D levels showed a significant (p < 0.001) reduction in respect to those in lactating and non lactating mothers and in non pregnant women too. Our results demonstrate that feto-maternal calcium metabolism is tightly related. Increased 1,25(OH)2D levels during pregnancy and lactation might be the maternal response to maintain an adequate supply via the placenta and via breast-milk. Mineral supply and vitamin D fetal status are providing by calcium, phosphorus and 25-OH-D placental tranfer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
