INTRODUCTION AND OBJECTIVES: Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS), is a novel technique that was developed to enable precise, image-guided targeting and destruction of tumors by thermocoagulation. The system, ExAblate for Prostate, is a focused ultrasound delivery system embedded within the MRI table of a conventional diagnostic MRI scanner. The device delivers ultrasound energy by a phased array transducer that converge it to selectively destroy the targeted tissue. Temperature maps generated by the MRI scanner are used to verify location and thermal rise, which are used to predict the thermal destruction in a real time closed loop feedback. To assess the safety, feasibility, and precision of this technology in the prostate, we have used the ExAblate for Prostate system to create thermal lesions in the prostate of dogs. METHODS: METHODS: Twenty dogs were anesthetized and positioned in the ExAblate for Prostate system. The dogs’ prostates were evaluated by the MRI for size and consistency. Local ablations were performed by the ExAblate for Prostate. The animals were then sacrificed. Prostates and the anterior rectal wall were removed for pathological study. The lesions were assessed macroscopically and histologically. The size, location and shape of accumulated thermal dose were compared with the post treatment contrast enhanced MRI scans and pathological specimen. Among the last 6 dogs, the transrectal
COMBINED ANESTHESIA WITH PERIANAL-INTRARECTAL LIDOCAINE-PRILOCAINE CREAM AND PERIPROSTATIC NERVE BLOCK DURING TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY: A RANDOMIZED CONTROLLED TRIAL
MOGOROVICH, ANDREA;MANASSERO, FRANCESCA;MORELLI, GIROLAMO;SELLI, CESARE
2009-01-01
Abstract
INTRODUCTION AND OBJECTIVES: Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS), is a novel technique that was developed to enable precise, image-guided targeting and destruction of tumors by thermocoagulation. The system, ExAblate for Prostate, is a focused ultrasound delivery system embedded within the MRI table of a conventional diagnostic MRI scanner. The device delivers ultrasound energy by a phased array transducer that converge it to selectively destroy the targeted tissue. Temperature maps generated by the MRI scanner are used to verify location and thermal rise, which are used to predict the thermal destruction in a real time closed loop feedback. To assess the safety, feasibility, and precision of this technology in the prostate, we have used the ExAblate for Prostate system to create thermal lesions in the prostate of dogs. METHODS: METHODS: Twenty dogs were anesthetized and positioned in the ExAblate for Prostate system. The dogs’ prostates were evaluated by the MRI for size and consistency. Local ablations were performed by the ExAblate for Prostate. The animals were then sacrificed. Prostates and the anterior rectal wall were removed for pathological study. The lesions were assessed macroscopically and histologically. The size, location and shape of accumulated thermal dose were compared with the post treatment contrast enhanced MRI scans and pathological specimen. Among the last 6 dogs, the transrectalI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
