Both types of diabetes are characterized by beta-cell failure and death, leading to insulin insufficiency. Very limited information is currently available about the ultrastructural alterations of beta cells in human diabetes. Our aim was to provide a comprehensive ultrastructural analysis of human pancreatic islets in type 1 (T1D) and type 2 (T2D) diabetic patients.
Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus
MASINI, MATILDE;MARTINO, LUISA;MARSELLI, LORELLA;BUGLIANI, MARCO;BOGGI, UGO;FILIPPONI, FRANCO;MARCHETTI, PIERO;DE TATA, VINCENZO
2017-01-01
Abstract
Both types of diabetes are characterized by beta-cell failure and death, leading to insulin insufficiency. Very limited information is currently available about the ultrastructural alterations of beta cells in human diabetes. Our aim was to provide a comprehensive ultrastructural analysis of human pancreatic islets in type 1 (T1D) and type 2 (T2D) diabetic patients.File in questo prodotto:
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Diabetes_Metabolism_Research_and_Reviews-2017.pdf
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