Background: Increased brachial artery (BA) stiffness has previously been shown to affect the magnitude of FMD response in patients with high cardio-vascular risk. However, it is unclear whether increased BA stiffness explains the diminished FMD response typically observed in a healthy older popula-tion. We determined whether BA stiffness would be greater in the older than the young population, and whether it would influence FMD responses in the former. Methods: Data from 33 young (YNG: 27.5 4.9yrs) and 33 older (OLD: 64.9 3.6yrs) individuals were analysed. FMD was assessed with reactive hyperaemia using Ultrasound Advanced Open Platform (ULA-OP). All ac-quired raw data were post-processed using custom-designed software to obtain parameters of WSR and diameter. BA stiffness was calculated from BA systolic and diastolic diameters with simultaneous contra-lateral BA blood pressure measurements, and was expressed as pulse wave velocity (PWV) and b-stiffness index. Results: Both PWV [YNG: 9.5(8.710.3) vs OLD: 9.4(8.6e10.2) m/s] and b-stiffness index [YNG: 17.5(14.7e20.2) vs OLD: 16.7(13.9e19.4) au] were similar between populations. In YNG, there was no association between BA stiffness parameters and diameter changes obtained during FMD and nitro-glycerin-mediated dilatation assessments. The association was also absent in OLD during either assessment. Conclusions: These results demonstrate that BA stiffness is not increased in the healthy older population compared to the young counterpart. Further-more, there is no association between BA stiffness parameters and the FMD response in either population, suggesting that BA stiffness may not in-fluence BA vasodilatory response in healthy adults.

Influence of brachial artery stiffness on flow-mediated dilatation in healthy young and older populations

Carmela Morizzo;Carlo Palombo
2017-01-01

Abstract

Background: Increased brachial artery (BA) stiffness has previously been shown to affect the magnitude of FMD response in patients with high cardio-vascular risk. However, it is unclear whether increased BA stiffness explains the diminished FMD response typically observed in a healthy older popula-tion. We determined whether BA stiffness would be greater in the older than the young population, and whether it would influence FMD responses in the former. Methods: Data from 33 young (YNG: 27.5 4.9yrs) and 33 older (OLD: 64.9 3.6yrs) individuals were analysed. FMD was assessed with reactive hyperaemia using Ultrasound Advanced Open Platform (ULA-OP). All ac-quired raw data were post-processed using custom-designed software to obtain parameters of WSR and diameter. BA stiffness was calculated from BA systolic and diastolic diameters with simultaneous contra-lateral BA blood pressure measurements, and was expressed as pulse wave velocity (PWV) and b-stiffness index. Results: Both PWV [YNG: 9.5(8.710.3) vs OLD: 9.4(8.6e10.2) m/s] and b-stiffness index [YNG: 17.5(14.7e20.2) vs OLD: 16.7(13.9e19.4) au] were similar between populations. In YNG, there was no association between BA stiffness parameters and diameter changes obtained during FMD and nitro-glycerin-mediated dilatation assessments. The association was also absent in OLD during either assessment. Conclusions: These results demonstrate that BA stiffness is not increased in the healthy older population compared to the young counterpart. Further-more, there is no association between BA stiffness parameters and the FMD response in either population, suggesting that BA stiffness may not in-fluence BA vasodilatory response in healthy adults.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/884057
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