Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1Ã10-10), 3p22.1 (rs67311347, P = 2.5Ã10-8), 3q26.2 (rs10936602, P = 8.8Ã10-9), 8p21.3 (rs2241261, P = 5.8Ã10-9), 10q24.33-q25.1 (rs11813268, P = 3.9Ã10-8), 11q22.3 (rs74911261, P = 2.1Ã10-10) and 14q24.2 (rs4903064, P = 2.2Ã10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
Baglietto, Laura;
2017-01-01
Abstract
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1Ã10-10), 3p22.1 (rs67311347, P = 2.5Ã10-8), 3q26.2 (rs10936602, P = 8.8Ã10-9), 8p21.3 (rs2241261, P = 5.8Ã10-9), 10q24.33-q25.1 (rs11813268, P = 3.9Ã10-8), 11q22.3 (rs74911261, P = 2.1Ã10-10) and 14q24.2 (rs4903064, P = 2.2Ã10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.File | Dimensione | Formato | |
---|---|---|---|
Scelo-ncomms15724.pdf
accesso aperto
Tipologia:
Versione finale editoriale
Licenza:
Creative commons
Dimensione
377.41 kB
Formato
Adobe PDF
|
377.41 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.