RESERVOIR PRESSURE INTEGRAL IS INDEPENDENTLY ASSOCIATED WITH THE REDUCTION IN RENAL FUNCTION IN AN OLDER POPULATION

Background: Central haemodynamic parameters derived from reservoir pressure analysis (RPA-parameters) exhibit prognostic utility. Alterations in reservoir function could have an unfavourable influence on target organs, such as the kidneys. We determined in older adults whether these RPA-pa- rameters would be associated with the reduction in estimated glomerular filtration rate (eGFR) during a 3-year follow-up period. Methods: We studied 544 individuals (69.4 7.9 yrs, 195F, 235CVD) at base- line and after 3 years. RPA-parameters including reservoir pressure integral (INTPR), peak reservoir pressure, excess pressure integral, systolic and dia- stolic rate constants were obtained by radial artery tonometry. Results: After 3 years, 95 individuals (72.4 7.6 yrs, 26F) had an eGFR reduction of more than 5 ml/min/1.73 m2/year. A multivariate logistic regression analysis revealed that baseline INTPR was independently associ- ated with the eGFR reduction after adjusting for conventional risk factors and baseline renal function [odds ratio 0.975 (95% CI, 0.958e0.993), p < 0.01].