%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
application/pdf
doi:10.1038/s41598-017-00854-w
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis
Karla Misselbeck
Luca Marchetti
Martha S. Field
Marco Scotti
Corrado Priami
Patrick J. Stover
Springer US
Scientific Reports, doi:10.1038/s41598-017-00854-w
10.1038/s41598-017-00854-w
http://dx.doi.org/10.1038/s41598-017-00854-w
journal
Scientific Reports
© 0, The Author(s)
2045-2322
1
12
noindex
10.1038/s41598-017-00854-w
2010-04-23
springer.com
springerlink.com
2010-04-23
True
10.1038/s41598-017-00854-w
springer.com
springerlink.com
Springer
2017-04-05T14:53:59+02:00
2017-04-04T17:38:57+05:30
2017-04-05T14:53:59+02:00
True
iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
uuid:da951285-6f1b-4280-9738-8006cfc8b867
uuid:0e7074d2-5964-4059-a2e4-411244673482
endstream
endobj
3 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>/ColorSpace<>/Font<>>>/TrimBox[0.0 0.0 595.276 782.362]/Thumb 17 0 R/MediaBox[0.0 0.0 595.276 782.362]/BleedBox[0.0 0.0 595.276 782.362]/ArtBox[0.0 0.0 595.276 782.362]/Annots 18 0 R/Rotate 0>>
endobj
18 0 obj
[19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
endobj
19 0 obj
<>/Subtype/Link/Rect[486.594 400.87 492.294 388.612]/H/N>>
endobj
20 0 obj
<>/Subtype/Link/Rect[495.378 400.87 501.079 388.612]/H/N>>
endobj
21 0 obj
<>/Subtype/Link/Rect[537.883 370.753 543.671 358.612]/H/N>>
endobj
22 0 obj
<>/Subtype/Link/Rect[546.798 370.753 552.586 358.612]/H/N>>
endobj
23 0 obj
<>/Subtype/Link/Rect[257.836 340.753 263.452 328.612]/H/N>>
endobj
24 0 obj
<>/Subtype/Link/Rect[354.337 310.753 359.953 298.612]/H/N>>
endobj
25 0 obj
<>/Subtype/Link/Rect[362.482 310.753 368.098 298.612]/H/N>>
endobj
26 0 obj
<>/Subtype/Link/Rect[399.44 290.753 405.131 278.612]/H/N>>
endobj
27 0 obj
<>/Subtype/Link/Rect[407.827 290.753 413.518 278.612]/H/N>>
endobj
28 0 obj
<>/Subtype/Link/Rect[187.425 270.753 193.041 258.612]/H/N>>
endobj
29 0 obj
<>/Subtype/Link/Rect[507.254 210.753 512.975 198.612]/H/N>>
endobj
30 0 obj
<>/Subtype/Link/Rect[546.962 190.753 552.586 178.612]/H/N>>
endobj
31 0 obj
<>/Subtype/Link/Rect[374.38 100.87 378.677 88.6122]/H/N>>
endobj
32 0 obj
<>/Subtype/Link/Rect[235.109 80.7532 240.813 68.6122]/H/N>>
endobj
33 0 obj
<>/Subtype/Link/Rect[202.158 60.7532 206.515 48.6122]/H/N>>
endobj
34 0 obj
<>/Subtype/Link/Rect[164.242 508.007 169.858 495.749]/H/N>>
endobj
5 0 obj
<>stream
HWێ}<"%@$Xi'ܒڭĖ=Vg:ER۽Du=u_Mv{y{Qifd֏w:UG?yVrV]d>>V5^?NJS֍JIjlUa+Yrcߢ&NWytY>dTtKzKG{zCo|QqF[YBZ>Xrv_F).ys9*w^mE[9>ѣO#UÆg
^cs:hM 7yTӒy_Sk!IF;I),Gbm-C(_`3V!4//v
Ay3_qsvg)^L}ܗ8%~۽|z䣲7 ApSdؕ"+ݡ5Wc]*9L-'*dHC}lV!m3YZI`(Quw
kI_zQJJ!="XvΡ1uvڟ
́g]&ӛ'A~qP%ilJs#uL$~#4[vAoIȚ8*|+x"EeU]j- *C@s^®2 GscYj4ׇ='^9;Y]-0miPE.R ׆;3[E"Cr3