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A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1 1-gen-2016 Giovannetti, Elisa; Leon, Leticia G.; Gómez, Valentina E.; Zucali, Paolo A.; Minutolo, Filippo; Peters, Godefridus J.
Abstract 3082: Targeting hypoxic pancreatic cancer cells with glucose conjugated lactate dehydrogenase inhibitor NHI-Glc-2 1-gen-2019 Hassouni, Btissame El; Sciarrillo, Rocco; Gómez, Valentina Edith; Maftouh, Mina; Mantini, Giulia; Vonk, Christian M.; Granchi, Carlotta; Funel, Niccola; Minutolo, Filippo; Peters, Godefridus J.; Giovannetti, Elisa
Array-based comparative genomic hybridization analysis to identify prognostic markers for resected pancreatic cancer. 1-gen-2011 Jih Hsiang, Lee; Petrini, Iacopo; Jin Hyeok, Hwang; Giovannetti, Elisa; Johannes, Voortman; Yonghong, Wang; Seth M, Steinberg; Paul S, Meltzer; Yisong, Wang; Giuseppe, Giaccone
Blood platelet RNA yields a new diagnostic prospective for accurate detection and staging of pancreatic ductal adenocarcinoma 1-gen-2020 Boyd, L.; Meijer, L.; In 't Veld, S.; Le Large, T.; Best, M.; Lelij E., Van Der; Dwarshuis, G.; Sol, N.; Mantini, G.; Capula, M.; Frampton, A.; Morelli, L.; Arkani, M.; Post, E.; Zonderhuis, B.; Daams, F.; Besselink, M.; Bijlsma, M.; Giovannetti, E.; Wurdinger, T.; Kazemier, G.
Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma. 1-gen-2013 Avan, A; Caretti, V; Funel, Niccola; Galvani, E; Maftouh, M; Honeywell, Rj; Lagerweij, T; Van Tellingen, O; Campani, Daniela; Fuchs, D; Verheul, Hm; Schuurhuis, Gj; Boggi, Ugo; Peters, Gj; Würdinger, T; Giovannetti, Elisa
Diagnostic probes to detect cells and tissues afflicted with a pathological or metabolic condition by means of infrared spectroscopy 1-gen-2021 Minutolo, Filippo; DI BUSSOLO, Valeria; Granchi, Carlotta; Funel, Niccola; Giovannetti, Elisa; Sartini, Stefania; Bononi, Giulia; DI PIETRO, Sebastiano; Fortunato, Serena; Paltrinieri, Erica; Cicio, Gaspare; Iaccarino, Rita
Genetic variation: effect on prostate cancer 1-gen-2014 Sissung, Tm; Price, Dk; DEL RE, Marzia; Ley, Am; Giovannetti, Elisa; Figg, Wd; Danesi, Romano
GLUT1 and LOX inhibitors as perspective anticancer agents tackling glucose avidity and ECM remodeling in tumors 1-gen-2018 Granchi, C.; Bononi, G.; Fortunato, S.; Tuccinardi, T.; Funel, N.; Firuzi, O.; Peters, G. J.; Giovannetti, E.; Minutolo, F.
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds 1-gen-2020 Li Petri, G.; El Hassouni, B.; Sciarrillo, R.; Funel, N.; Mantini, G.; Zeeuw van der Laan, E. A.; Cascioferro, S.; Avan, A.; Zucali, P. A.; Zaffaroni, N.; Lagerweij, T.; Parrino, B.; Smid, K.; Deraco, M.; Granchi, C.; Braczko, A.; Smolenski, R. T.; Matherly, L. H.; Jansen, G.; Assaraf, Y. G.; Diana, P.; Cloos, J.; Peters, G. J.; Minutolo, F.; Giovannetti, E.
Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction 1-gen-2020 Granchi, Carlotta; Minutolo, Filippo; Giovannetti, Elisa
MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside. 1-gen-2014 Avan, A; Maftouh, M; Funel, Niccola; Ghayour Mobarhan, M; Boggi, Ugo; Peters, Gj; Giovannetti, Elisa
Omics Analysis of Educated Platelets in Cancer and Benign Disease of the Pancreas 1-gen-2020 Mantini, Giulia; Meijer, Laura L; Glogovitis, Ilias; In 't Veld, Sjors G J G; Paleckyte, Rosita; Capula, Mjriam; Le Large, Tessa Y S; Morelli, Luca; Pham, Thang V; Piersma, Sander R; Frampton, Adam E; Jimenez, Connie R; Kazemier, Geert; Koppers-Lalic, Danijela; Wurdinger, Thomas; Giovannetti, Elisa
Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer 1-gen-2017 Massihnia, Daniela; Avan, Amir; Funel, Niccola; Maftouh, Mina; Van Krieken, Anne; Granchi, Carlotta; Raktoe, Rajiv; Boggi, Ugo; Aicher, Babette; Minutolo, Filippo; Russo, Antonio; Leon, Leticia G.; Peters, Godefridus J.; Giovannetti, Elisa
Role of CYB5A in pancreatic cancer prognosis and autophagy modulation. 1-gen-2014 Giovannetti, Elisa; Wang, Q; Avan, A; Funel, Niccola; Lagerweij, T; Lee, Jh; Caretti, V; van der Velde, A; Boggi, Ugo; Wang, Y; Vasile, E; Peters, Gj; Wurdinger, T; Giaccone, G.
Sonde diagnostiche per evidenziare all’infrarosso cellule e tessuti affetti da condizioni patologiche o metaboliche 1-gen-2020 Minutolo, Filippo; DI BUSSOLO, Valeria; Granchi, Carlotta; Funel, Niccola; Giovannetti, Elisa; Sartini, Stefania; Bononi, Giulia; DI PIETRO, Sebastiano; Cicio, Gaspare; Fortunato, Serena; Paltrinieri, Erica; Iaccarino, Rita
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia. 1-gen-2014 Maftouh, M; Avan, A; Sciarrillo, R; Granchi, Carlotta; Leon, Lg; Rani, R; Funel, Niccola; Smid, K; Honeywell, R; Boggi, Ugo; Minutolo, F; Peters, Gj; Giovannetti, Elisa
The biology of regulatory pathways of miRNAs, mRNAs and proteins unravels a specific -omics network in tumor-educated platelets from pancreatic cancer patients 1-gen-2020 Capula, M.; Mantini, G.; Meijer, L.; Le Large, T.; Kazemier, G.; Veld G., In T.; Boyd, L.; Di Franco, G.; Funel, N.; Palmeri, M.; Morelli, L.; Wurdinger, T.; Jimenez, C.; Koppers, D.; Giovannetti, E.
The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies 1-gen-2020 El Hassouni, B.; Granchi, C.; Valles-Marti, A.; Supadmanaba, I. G. P.; Bononi, G.; Tuccinardi, T.; Funel, N.; Jimenez, C. R.; Peters, G. J.; Giovannetti, E.; Minutolo, F.
The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells 1-gen-2022 Franczak, Marika; Kutryb-Zajac, Barbara; El Hassouni, Btissame; Giovannetti, Elisa; Granchi, Carlotta; Minutolo, Filippo; Smolenski, Ryszard T; Peters, Godefridus J
The MEK1/2 inhibitor pimasertib enhances gemcitabine efficacy-letter 1-gen-2016 Leon, Leticia G.; Funel, Niccola; Peters, Godefridus J.; Avan, Amir; Vistoli, Fabio; Boggi, Ugo; Giovannetti, Elisa