Statement of Purpose: The development of therapies against musculoskeletal disorders is hindered by the lack of veritable in vitro osteochondral (OC) models (1). In this work, we have developed a microphysiological vascular-osteo-chondral (µVOC) triphasic model within a unique 3D printed multiphasic tissue system bioreactor (2) that allows the separate flow of specific media to the chondral and osseous components, while maintain them in contact and allowing tissue-tissue communication (3).
An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex
Pirosa A.;Puppi D.;Chiellini F.;
2019-01-01
Abstract
Statement of Purpose: The development of therapies against musculoskeletal disorders is hindered by the lack of veritable in vitro osteochondral (OC) models (1). In this work, we have developed a microphysiological vascular-osteo-chondral (µVOC) triphasic model within a unique 3D printed multiphasic tissue system bioreactor (2) that allows the separate flow of specific media to the chondral and osseous components, while maintain them in contact and allowing tissue-tissue communication (3).File in questo prodotto:
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