The neuronal regeneration in injuries that present gaps between the neuronal stumps is one of the most amazing sector of research of Regenerative Medicine. In order to obtain a perfect and functional alignment of neuronal fibres several techniques for bridging defects in peripheral nerve have been developed, in particular the implant of biodegradable polymeric guidance channels has shown considerable results. In this study preliminarily polyurethane-based nerve guide have been realised whit an extrusion system and then filled with specific cell adhesion biomolecules (gelatine and polylisine). This guides have been tested in vitro and in vivo. In particular during in-vivo experiments an accurate electromyography on the rat before the explant and histology of explanted tube were performed.
VALUTAZIONE DELL'"EFFETTO TUNNEL" MEDIANTE TUBI BIOERODIBILI NELLA NERVE REGENERATION
CARLUCCI, FABIO;VOZZI, GIOVANNI;SALVADORI, CLAUDIA;
2006-01-01
Abstract
The neuronal regeneration in injuries that present gaps between the neuronal stumps is one of the most amazing sector of research of Regenerative Medicine. In order to obtain a perfect and functional alignment of neuronal fibres several techniques for bridging defects in peripheral nerve have been developed, in particular the implant of biodegradable polymeric guidance channels has shown considerable results. In this study preliminarily polyurethane-based nerve guide have been realised whit an extrusion system and then filled with specific cell adhesion biomolecules (gelatine and polylisine). This guides have been tested in vitro and in vivo. In particular during in-vivo experiments an accurate electromyography on the rat before the explant and histology of explanted tube were performed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
