We present a tool for detecting long similar fragments that occur two or more times in a set of biological sequences. The problem has interesting applications in the analysis of biological sequences and their correlation, and becomes computationally challenging when a certain non negligible number of insertions, deletions and substitutions are allowed. For this reason exact exhaustive methods are hardly of practical use. In this paper we introduce a tool, FilmRed, that performs this task, and that manages instances whose size and parameters combination cannot be handled by any existing tool. This is achieved by using a filter as a preprocessing step, and by using the information that the filter has gathered also in the successive inference phase. To the best of our knowledge, FILMRED is the first ab initio tool that can deal with repeats occurring possibly several times, that have length of hundreds or thousands bases, and whose occurrences may differ in even more than 10% of their positions in terms of substitutions and indels.
Finding Long and Multiple repetitions with Edit Distance
PISANTI, NADIA;
2011-01-01
Abstract
We present a tool for detecting long similar fragments that occur two or more times in a set of biological sequences. The problem has interesting applications in the analysis of biological sequences and their correlation, and becomes computationally challenging when a certain non negligible number of insertions, deletions and substitutions are allowed. For this reason exact exhaustive methods are hardly of practical use. In this paper we introduce a tool, FilmRed, that performs this task, and that manages instances whose size and parameters combination cannot be handled by any existing tool. This is achieved by using a filter as a preprocessing step, and by using the information that the filter has gathered also in the successive inference phase. To the best of our knowledge, FILMRED is the first ab initio tool that can deal with repeats occurring possibly several times, that have length of hundreds or thousands bases, and whose occurrences may differ in even more than 10% of their positions in terms of substitutions and indels.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
