Purpose Background. Pulmonary embolism (PE) is the third-ranked cardiovascular cause of death in Western countries after acute coronary syndrome and acute stroke, with a mortality rate as high as 50-58% in haemodynamically unstable patients and 8-15% in haemodynamically stable ones. Multidetector computed tomography (MDCT) is currently considered the diagnostic gold standard for PE, due to its high sensitivity and specificity and its ability to provide direct detection of emboli with... Methods and Materials Patient selection. We evaluated 17 patients (male:female=15:2) with clinically suspected PE, age 48-83 years (average 71 years), body weight 52-73kg (average 62kg), and history of non-small cell lung carcinoma (NSCLC). Exclusion criteria were weight >80kg and serum creatinine >2mg/dL. Scan protocol§ Tube voltage 80kV Tube current 100-400mA with mA modulation (noise index 30) Rotation time / beam pitch 0.6s / 0.984:1 Detector configuration 64×0.625mm... Results Overall intravascular density was not significantly different between protocols A and B (531.2±172.3 HU vs 521.1±155.1 HU, respectively; p=0.6250). CT density of each sampled arterial branch was not significantly different with the two protocols. Beam hardening artifacts were moderate with both protocols A and B and did not significantly degrade the conspicuity of pulmonary arteries in any case. Homogeneity of intravascular enhancement was good with both... Conclusion Low radiation dose (80kV tube voltage), low CM volume (40mL) protocols for visualisation of pulmonary arteries with 64-row CT allow to achieve optimal and homogeneous intravascular enhancement without significant artifacts. With IDR kept constant, iodine concentration of CM does not affect intravascular enhancement. Compared with standard protocols, a smaller CM volume might imply a lower risk of renal toxicity in patients and reduced costs.
CT pulmonary angiography with 80kV and 40mL of iodinated contrast material: technical feasibility and comparison of vascular enhancement with iodixanol 320mgI/mL and iomeprol 400mgI/mL
NERI, EMANUELE;
2011-01-01
Abstract
Purpose Background. Pulmonary embolism (PE) is the third-ranked cardiovascular cause of death in Western countries after acute coronary syndrome and acute stroke, with a mortality rate as high as 50-58% in haemodynamically unstable patients and 8-15% in haemodynamically stable ones. Multidetector computed tomography (MDCT) is currently considered the diagnostic gold standard for PE, due to its high sensitivity and specificity and its ability to provide direct detection of emboli with... Methods and Materials Patient selection. We evaluated 17 patients (male:female=15:2) with clinically suspected PE, age 48-83 years (average 71 years), body weight 52-73kg (average 62kg), and history of non-small cell lung carcinoma (NSCLC). Exclusion criteria were weight >80kg and serum creatinine >2mg/dL. Scan protocol§ Tube voltage 80kV Tube current 100-400mA with mA modulation (noise index 30) Rotation time / beam pitch 0.6s / 0.984:1 Detector configuration 64×0.625mm... Results Overall intravascular density was not significantly different between protocols A and B (531.2±172.3 HU vs 521.1±155.1 HU, respectively; p=0.6250). CT density of each sampled arterial branch was not significantly different with the two protocols. Beam hardening artifacts were moderate with both protocols A and B and did not significantly degrade the conspicuity of pulmonary arteries in any case. Homogeneity of intravascular enhancement was good with both... Conclusion Low radiation dose (80kV tube voltage), low CM volume (40mL) protocols for visualisation of pulmonary arteries with 64-row CT allow to achieve optimal and homogeneous intravascular enhancement without significant artifacts. With IDR kept constant, iodine concentration of CM does not affect intravascular enhancement. Compared with standard protocols, a smaller CM volume might imply a lower risk of renal toxicity in patients and reduced costs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
