Objective: to identify perinatal factors associated with sub-optimal neuromotor outcome in infants without evident CNS lesions (intraventricular haemorrhage/periventricular leukomalacia), with gestational age ≤30 (group I) and of 31-32 weeks (group II). Patients and methods: A total of 102 premature infants admitted to the Neonatal Intensive Care Unit of Pisa, at 26-32 weeks of gestation, were studied. Informations about perinatal factors and TSH values at 3-4 days of life were collected. The assessment of neuromotor development was performed at 18 months of corrected age, using the locomotor subscale of the Griffiths Scales of Mental Development . Results: risk factors supposed to be predictive of sub-optimal neuromotor outcome (odds ratio >1) were at ≤30 weeks: male sex, Small for Gestational Age, Patent Duct Arterious, Respiratory Distress Syndrome and at 31-32 weeks: Apgar at 5'<7, Respiratory Distress Syndrome, Patent Duct Arterious and birthweight <1500 grams. A strong correlation was also found between TSH screening values >4,3 mU/l and sub-optimal neuromotor outcome in both groups. Conclusions: several perinatal factors, acting on an immature and more vulnerable nervous system, such as the preterm one, different for different gestational ages, are associated with a sub-optimal neuromotor outcome. Higher, but within the normal range, TSH values at screening seem to be a strong risk factor for neuromotor outcome in preterm infants without intraventricular haemorrhage or periventricular leukomalacia.
|Autori interni:||TONACCHERA, MASSIMO|
|Autori:||BELCARI F; PLACIDI G; GUZZETTA A; TONACCHERA M; CIAMPI M; BARTOLI A; SCARAMUZZO RT; FRUMENTO P; CIONI G; PINCHERA A; BOLDRINI A; GHIRRI P|
|Titolo:||TSH levels in the first days of life and perinatal factors associated with suboptimal neuromotor outcome in preterm infants|
|Anno del prodotto:||2011|
|Appare nelle tipologie:||1.1 Articolo in rivista|