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Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling

Adenosine A2A receptor (A2AR)-dependent signaling in macrophages plays a key role in the regulation of inflammation. However, the processes regulating A2AR targeting to the cell surface and degradation in macrophages are incompletely understood. For example, the C-terminal domain of the A2AR and proteins interacting with it are known to regulate receptor recycling, although it is unclear what role potential A2AR-interacting partners have in macrophages. Here we aimed to identify A2AR interact...

Mitochondrial Ataxias: Molecular Classification and Clinical Heterogeneity

Ataxia is increasingly being recognized as a cardinal manifestation in primary mitochondrial diseases (PMDs) in both paediatric and adult patients. It can be caused by disruption of cerebellar nuclei or fibres, its connection with the brainstem, or spinal and peripheral lesions leading to proprioceptive loss. Despite mitochondrial ataxias having no specific defining features, they should be included in hereditary ataxias differential diagnosis, given the high prevalence of PMDs. This review f...

Bobbio e la pace necessaria

Riflessione sul pacifismo giuridico, a partire dalla guerra in Ucraina.

Search for Lepton Flavor Violation in Y (3S) → e ± µ±

We report on the first search for electron-muon lepton flavor violation (LFV) in the decay of a b quark and b antiquark bound state. We look for the LFV decay ?(3S)?e±µ± in a sample of 118 million ?(3S) mesons from 27 fb-1 of data collected with the BABAR detector at the SLAC PEP-II e+e- collider operating with a 10.36 GeV center-of-mass energy. No evidence for a signal is found, and we set a limit on the branching fraction B[?(3S)?e±µ±]<3.6×10-7 at 90% C. L. This result can be interpreted...

On the proper choice of datasets and traffic features for realtime anomaly detection

Thanks to its ability to face unknown attacks, Anomaly-based Intrusion Detection is a key research topic in network security and different statistical methods, fed by suitable traffic features, have been proposed in the literature. The choice of a proper dataset is a critical element not only for performance comparison, but also for the correct identification of the normal traffic behaviour. In this paper we address the general problem of selecting traffic features from recent real traffic tr...

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