The aim of this work was the development and characterization of a biomimetic cardiac patch, taking inspiration from nature at different levels: - in the choice of the materials for scaffold fabrication: a polysaccharide/proteins blend was used, to mimic the composition and the interactions of the cardiac ECM; - in the fabrication design: microfabrication techniques were emploted to mimic cardiac ECM architecture and anisotropy; - in the development of a bioactive microenvironment containing biochemical signals, by using Molecular Imprinting technology. Results obtained in this work showed that microfabricated scaffolds functionalized with MIP-YIGSR represent a promising cardia patch solution.
A Microfabricated Alginate/Gelatin/Elastin Cardiac Patch functionalized by Molecular Imprinting Technology
ROSELLINI, ELISABETTA;CASCONE, MARIA GRAZIA;BARBANI, NICCOLETTA;LAZZERI, LUIGI;
2015-01-01
Abstract
The aim of this work was the development and characterization of a biomimetic cardiac patch, taking inspiration from nature at different levels: - in the choice of the materials for scaffold fabrication: a polysaccharide/proteins blend was used, to mimic the composition and the interactions of the cardiac ECM; - in the fabrication design: microfabrication techniques were emploted to mimic cardiac ECM architecture and anisotropy; - in the development of a bioactive microenvironment containing biochemical signals, by using Molecular Imprinting technology. Results obtained in this work showed that microfabricated scaffolds functionalized with MIP-YIGSR represent a promising cardia patch solution.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
