Andromachia igniaria Humb. & Bonpl. (Asteraceae family) is a species widely distributed in the Andes mainly from Colombia and Ecuador [1]. In popular medicine people use the leaves to wash the body for purification, to treat headache or to heal wounds. Few information are reported about previous investigations carried out on some species of Andromachia genus, from Central and South America, that result basically on the isolation of some simple sesquiterpene lactones, triterpenes, and flavonoids [2-4]. The dried and powdered aerial parts of A. igniaria were sequentially extracted with n-hexane, CHCl3, CHCl3-MeOH (9:1) and MeOH. The MeOH extract was partitioned between n-BuOH and H2O and the n-BuOH fraction was preliminary eluted on Sephadex LH-20 column then, fractions obtained were subjected to RP-HPLC. NMR analysis underlined the presence of 15 known compounds of which 2 were new flavonoids characterized as 3',4',7,8-tetrahydroxyflavanone 7-O-(6''-O-acetyl)-β-D-glucopyranoside or 6''-O-acetylflavanomarein and 3',4',7,8-tetrahydroxyflavone 7-O-(6''-O-acetyl)-β-D-glucopyranoside. The hypoglycaemic properties of known and new compounds were also evaluated measuring extracts and pure compounds α-amylase and α-glucosidase inhibitory effects.
Hypoglicemic properties of secondary metabolites from Andromachia ignaria Humb. & Bonpl
BRACA, ALESSANDRA;
2015-01-01
Abstract
Andromachia igniaria Humb. & Bonpl. (Asteraceae family) is a species widely distributed in the Andes mainly from Colombia and Ecuador [1]. In popular medicine people use the leaves to wash the body for purification, to treat headache or to heal wounds. Few information are reported about previous investigations carried out on some species of Andromachia genus, from Central and South America, that result basically on the isolation of some simple sesquiterpene lactones, triterpenes, and flavonoids [2-4]. The dried and powdered aerial parts of A. igniaria were sequentially extracted with n-hexane, CHCl3, CHCl3-MeOH (9:1) and MeOH. The MeOH extract was partitioned between n-BuOH and H2O and the n-BuOH fraction was preliminary eluted on Sephadex LH-20 column then, fractions obtained were subjected to RP-HPLC. NMR analysis underlined the presence of 15 known compounds of which 2 were new flavonoids characterized as 3',4',7,8-tetrahydroxyflavanone 7-O-(6''-O-acetyl)-β-D-glucopyranoside or 6''-O-acetylflavanomarein and 3',4',7,8-tetrahydroxyflavone 7-O-(6''-O-acetyl)-β-D-glucopyranoside. The hypoglycaemic properties of known and new compounds were also evaluated measuring extracts and pure compounds α-amylase and α-glucosidase inhibitory effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.