Cryptococcus neoformans is an opportunistic pathogen that causes severe diseases and death in immunocompromised individuals. The cell wall of C. neoformans is surrounded by a polysaccharide capsule, which is the main virulence factor and thus a potential target for the development of a capsular polysaccharide based vaccine. The synthetic approaches to prepare part structures of the polysaccharide capsule are described together with the recent efforts to identify a protective epitope against this pathogen.
How to Identify Protective Carbohydrate Epitopes in the Development of a Glycoconjugate Vaccine Against Cryptococcus neoformans
GUAZZELLI, LORENZO;
2015-01-01
Abstract
Cryptococcus neoformans is an opportunistic pathogen that causes severe diseases and death in immunocompromised individuals. The cell wall of C. neoformans is surrounded by a polysaccharide capsule, which is the main virulence factor and thus a potential target for the development of a capsular polysaccharide based vaccine. The synthetic approaches to prepare part structures of the polysaccharide capsule are described together with the recent efforts to identify a protective epitope against this pathogen.File in questo prodotto:
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