Pyridine- and phosphine-based ligands modified with ethacrynic acid (EA, i.e. a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes.1 All the compounds (ligands and complexes) were fully characterized by analytical and spectroscopic methods and, in one case, by single-crystal X-ray diffraction. The in vitro anticancer activity of the compounds was studied towards two different tumour cell lines. The antiproliferative activity of the compounds and the possible role exerted by the EA-functionalized ligands will be discussed.
Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic Acid-Modified Ligands
AGONIGI, GABRIELE;BIANCALANA, LORENZO;CHIELLINI, FEDERICA;FUNAIOLI, TIZIANA;GABBIANI, CHIARA;MARCHETTI, FABIO;PAMPALONI, GUIDO;
2016-01-01
Abstract
Pyridine- and phosphine-based ligands modified with ethacrynic acid (EA, i.e. a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes.1 All the compounds (ligands and complexes) were fully characterized by analytical and spectroscopic methods and, in one case, by single-crystal X-ray diffraction. The in vitro anticancer activity of the compounds was studied towards two different tumour cell lines. The antiproliferative activity of the compounds and the possible role exerted by the EA-functionalized ligands will be discussed.File in questo prodotto:
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