A mechanistic, thermodynamic and kinetic analysis of the binding of the Pd(II)/5,10,15,20-tetrakis(1-methyl-4-pyridiyl)-porphyrine metal complex is done. Fluorescence and absorbance titrations under different conditions of temperature and salt content concur in indicating that the binding is strong. Kinetic and equilibrium parameters for the complex interaction with the nucleic acid are obtained and the binding mechanism is discussed. An intercalative binding is found to be active.
Interaction of the Pd(II) complex of 5,10,15,20-tetrakis(1-methyl-4-pyridiyl)-porphyne with natural DNA
BIVER, TARITA
2015-01-01
Abstract
A mechanistic, thermodynamic and kinetic analysis of the binding of the Pd(II)/5,10,15,20-tetrakis(1-methyl-4-pyridiyl)-porphyrine metal complex is done. Fluorescence and absorbance titrations under different conditions of temperature and salt content concur in indicating that the binding is strong. Kinetic and equilibrium parameters for the complex interaction with the nucleic acid are obtained and the binding mechanism is discussed. An intercalative binding is found to be active.File in questo prodotto:
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