Catechins are natural flavonoids found in a variety of plant-derived beverages and edible vegetables. High concentrations of catechin can be found in green tea, red wine, chocolate and fruits. Consumption of catechins has been associated with beneficial effects including antioxidant activity, blood vessels expansion, decreased LDL oxidation, and reduced susceptibility to various cancer types. Natural catechin is very unstable and easily oxidable, but pharmacokinetics profiles of this drug could be easily modified by exploiting recent advances in the nanomedicine field. Specifically, two different nanoformulations were tested: gelatine-catechin conjugates and gelatine-catechin coniugates incorporating carbon nanotubes (CNT). Melanoma is a very aggressive cancer and a leading cause of death due to its highly metastatic ability. We investigated inhibitory effects of different catechin formulations on the invasive potential of human melanoma A375 cells by performing cytotoxicity, cell proliferation and cell invasion assays. In parallel, to investigate in vivo anti-tumor and anti-metastasis effects, we are employing transgenic zebrafish as model for human melanoma cell xenotransplants.
Inhibitory effects of different catechin formulations on tumor cells
M. Giannaccini;L. Dente;V. Raffa
2014-01-01
Abstract
Catechins are natural flavonoids found in a variety of plant-derived beverages and edible vegetables. High concentrations of catechin can be found in green tea, red wine, chocolate and fruits. Consumption of catechins has been associated with beneficial effects including antioxidant activity, blood vessels expansion, decreased LDL oxidation, and reduced susceptibility to various cancer types. Natural catechin is very unstable and easily oxidable, but pharmacokinetics profiles of this drug could be easily modified by exploiting recent advances in the nanomedicine field. Specifically, two different nanoformulations were tested: gelatine-catechin conjugates and gelatine-catechin coniugates incorporating carbon nanotubes (CNT). Melanoma is a very aggressive cancer and a leading cause of death due to its highly metastatic ability. We investigated inhibitory effects of different catechin formulations on the invasive potential of human melanoma A375 cells by performing cytotoxicity, cell proliferation and cell invasion assays. In parallel, to investigate in vivo anti-tumor and anti-metastasis effects, we are employing transgenic zebrafish as model for human melanoma cell xenotransplants.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
